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KMID : 1134820170460040523
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Journal of the Korean Society of Food Science and Nutrition
2017 Volume.46 No. 4 p.523 ~ p.528
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Effects of Extracts of Five Species of Korean Native Forest Plants on Lipid Accumulation and Reactive Oxygen Species Production during Differentiation of 3T3-L1 Preadipocytes
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Choi Sun-Il
Lee Jong-Seok
Lee Sa-Rah
Lee Hye-Jin
Yeo Joo-Hong
Cho Bong-Yeon
Lee Jin-Ha
Kim Jae-Min
Jung Tae-Dong
Choi Seung-Hyun
Kim Jong-Yea
Kang Suk-Nam
Lee Ok-Hwan
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Abstract
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This study investigate the effects of extracts of five species of Korean native forest plants on lipid accumulation and reactive oxygen species (ROS) production during the differentiation of 3T3-L1 cells. Our results show that Korean native forest plants extracts significantly reduced lipid accumulation and ROS production during adipogenesis in 3T3-L1 cells. Especially, Rubus coreanus Miq. was most effective in the inhibition of lipid accumulation and ROS production at a concentration of 100 μg/mL. Moreover, Rubus coreanus Miq. extracts significantly inhibited adipocyte differentiation, which is dependent on down-regulation of peroxisome proliferator-activated receptor gamma, CCAAT/enhancer-binding protein alpha, and adipocyte-specific fatty acid binding protein, a key adipogenic transcription factor. Therefore, these results suggest that Rubus coreanus Miq. might be a valuable source of bioactive compounds with anti-adipogenic activity.
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KEYWORD
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3T3-L1 cell, adipocyte differentiation, lipid accumulation, reactive oxygen species, Korean native forest plants
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